A kinase shRNA screen links LATS2 and the pRB tumor suppressor
نویسندگان
چکیده
منابع مشابه
LATS2 is a tumor suppressor gene of malignant mesothelioma.
Malignant mesothelioma (MM) is an aggressive neoplasm associated with asbestos exposure. We carried out genome-wide array-based comparative genomic hybridization analysis with 14 MM cell lines. Three cell lines showed overlapping homozygous deletion at chromosome 13q12, which harbored the LATS2 (large tumor suppressor homolog 2) gene. With 6 other MM cell lines and 25 MM tumors, we found 10 ina...
متن کاملAngiomotin family proteins are novel activators of the LATS2 kinase tumor suppressor
LATS2 kinase functions as part of the Hippo pathway to promote contact inhibition of growth and tumor suppression by phosphorylating and inhibiting the transcriptional coactivator YAP. LATS2 is activated by the MST2 kinase. How LATS2 is activated by MST2 in response to changes in cell density is unknown. Here we identify the angiomotin-family tight junction protein AMOTL2 as a novel activator o...
متن کاملEvidence for a tumor suppressor role for the large tumor suppressor genes LATS1 and LATS2 in human cancer.
The role of Large tumor suppressor LATS/Warts in human cancer is not clearly understood. Here we show that hLATS1/2 cancer mutations affect their expression and kinase activity. hLATS1/2 mutants exhibit a decreased activity in inhibiting YAP and tissue growth. Therefore, hLATS1/2 alleles from human cancer can be loss-of-function mutations.
متن کاملMolecular and Cellular Pathobiology LATS2 Is a Tumor Suppressor Gene of Malignant Mesothelioma
Malignant mesothelioma (MM) is an aggressive neoplasm associated with asbestos exposure. We carried out genome-wide array-based comparative genomic hybridization analysis with 14 MM cell lines. Three cell lines showed overlapping homozygous deletion at chromosome 13q12, which harbored the LATS2 (large tumor suppressor homolog 2) gene. With 6 otherMM cell lines and 25MM tumors, we found 10 inact...
متن کاملThe LATS2 tumor suppressor inhibits SREBP and suppresses hepatic cholesterol accumulation.
The Hippo signaling pathway is a major regulator of organ size. In the liver, Hippo pathway deregulation promotes hyperplasia and hepatocellular carcinoma primarily through hyperactivation of its downstream effector, YAP. The LATS2 tumor suppressor is a core member of the Hippo pathway. A screen for LATS2-interacting proteins in liver-derived cells identified the transcription factor SREBP2, ma...
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ژورنال
عنوان ژورنال: Genes & Development
سال: 2011
ISSN: 0890-9369
DOI: 10.1101/gad.2000211